ABSTRACT
Objective To develop medical emergency support information system for large-scale social activities based on 5G communication technology to improve efficiency of emergency medical services.Methods The project was completed in Hangzhou,China,from March 2016 to September 2019.Based on the medical service of large social activities,five information terminals are constructed,including on-site mobile terminal,on-board first aid terminal,expert remote consultation terminal,hospital terminal,and command dispatch center.The system can realize the real-time communication of medical information,patient's vital signs,audio,picture and video information,and can also make intelligent scheduling decisions for patients.Results 5G Emergency Medical information System for Large-scale Social Activities has been completed,which consists of three parts:command and control platform,onsite rescue platform,and evacuation support platform.The command and monitoring platform displays the information of on-site medical teams,ambulances,hospitals and experts through web pages,and realizes multi-party video communication at any time,as well as text,voice and image information of patients' current condition,so as to realize command,dispatch and display statistical summary information.On-site rescue terminal includes patient information input,video signal acquisition and physiological information acquisition equipment.It realizes multiple methods of patient information input,vital signs and physiological information acquisition,multi-angle video acquisition and transmission to the command center.The evacuation support platform includes vehicle emergency terminal,remote expert consultation terminal,hospital terminal and UAV system.Vehicle terminal can scan and transfer with on-site ambulance team,record physiological information during transit,and also acquire and transmit monitor,electrocardiogram and ultrasound information.Hospital terminals can obtain patient information at the first time and prepare for first-aid in hospital.The remote expert terminal can be dispatched by the command center and the hospital terminal,and can join the remote consultation at any time.Unmanned aerial vehicle (UAV) system can transfer medical material between any locations.Conclusions This system can guarantee the patients to be transported from the scene to the ambulance and finally to the hospital during the large-scale social activities.In the whole process,the information transmission and dispatching decision-making are initially realized,and the statistical report forms can be made.However,to fully exert its advantages,it still needs the support of the complete 5G network and continuous optimization in real scenarios.
ABSTRACT
Objective To explore the expression of eukaryocyte initiation factors-4E (eIF-4E) in normal esophageal epithelium and different esophageal lesions tissue and its relationship with vascular endothelial growth factor (VEGF).Methods Thirty normal esophageal incisal margin tissues,32 atypical hyperplasia tissues,20 carcinoma in situ tissues and 117 esophageal invasive carcinoma tissues were selected from the biopsy specimens of the Department of Pathology,the First Affiliated Hospital of Xinxiang Medical University from March 2014 to March 2016.The expression of eIF-4E and VEGF were detected by immunohistochemistry method and the correlation between them was analyzed.Results The positive expression rate of eIF-4E in normal esophageal epithelium,atypical hyperplasia,carcinoma in situ and invasive carcinoma tissues was 0.0％ (0/ 30),9.4％ (3/32),45.0％ (9/20) and 80.3％ (94/117) respectively.There was no statistic difference in the positive expression rate of eIF-4E in normal esophageal epithelium and atypical hyperplasia tissues (P ＞ 0.05);there was statistic difference in the positive expression rate of eIF-4E in the other esophageal tissues(P ＜ 0.05).In 117 invasive carcinoma tissues,the positive expression rate of eIF-4E in metastatic carcinoma tissues (93.2％,55/59) was significantly higher than that in the non metastatic carcinoma tissues (67.2％,39/58) (P ＜ 0.05).The positive expression rate of eIF-4E in esophageal carcinoma tissues which invaded into shallow muscle layer,deep muscular layer and adventitia was 70.0％ (28/40),73.8％ (31/42) and 100.0％ (35/ 35) respectively;there was no statistic difference in positive expression rate of eIF-4E in the carcinoma tissues which invaded into shallow muscle layer and deep muscular layer(P ＞ 0.05);the positive expression rate of eIF-4E in the carcinoma tissues which invaded into shallow muscle layer and deep muscular layer was significantly lower than that in the carcinoma tissues which invaded into adventitia(P ＜0.01).The expression of eIF-4E in the esophageal invasive carcinoma tissues was positive VEGF(x2 =51.460,P ＜ O.05).Conclusion eIF-4E play an important role in the canceration of normal esophageal and the invasion,metastasis of esophageal carcinoma.The expression of eIF-4E is correlate with VEGF in esophageal carcinoma tissues.